Vinorelbine is a chemotherapy drug that is given as a treatment for some types of cancer. Vinorelbine drug is currently in Phase II clinical trials as a treatment for ovarian cancer. Thus far, vinorelbine seems to have a wider range of antitumor activity than the other vinca alkaloids. In preclinical trials, it showed promise in treating patients with epithelial ovarian cancers and, in combination with the chemotherapy drug cisplatin, in treating patients with non-small-cell lung cancers.

E-DMF is under Preparation

(3,4,5-tri-methoxybenzoyloxy) As alkoloid obtain from the roots of certain species of Rauwolfia (Apocynaceae), mainly Rauwolfiaserpentina and R. vomitoria, or by synthesis. The material obtained from natural sources may contain closely related alkaloids.

It occurs as odourless, almost tasteless, fine white or pale buffto slightly yellow coloured crystals or crystalline powder. M.p about 270 degrees with decomposition. It darkens slowly on exposure to light but more rapidly when in solution.

Practically insoluble in water and ether ; soluble in 1 in 2000 of alcohol, 1 in 90 of acetone, 1 in 6 of chloroform and 1 in 2000 of methyl alcohol; freely soluble in acetic acid. A solution in chloroform in laevorotatory. solutions may be sterilised by filteration. Store in airtight containers. Protect from light.

Reserpine and its preperations discoloured rapidly when exposed to light but loss in potency was usually small solutions.

Intensive combination chemotherapy with regimens including vincristine has been shown to result in increased risks for acute nonlymphatic leukemia (ANLL). In the presence of concurrent therapy with other putative carcinogens, including ionizing radiation and other potent drugs, occasional case reports of exposure to vincristine sulphate do not constitute evidence of carcinogenesis.

Intensive combination chemotherapy with regimens including vincristine has been shown to result in increased risks for acute nonlymphatic leukemia (ANLL). In the presence of concurrent therapy with other putative carcinogens, including ionizing radiation and other potent drugs, occasional case reports of exposure to vincristine sulphate do not constitute evidence of carcinogenesis.
We can also provide E-DMF

Sulphasalazine can reduce the symptoms and slow the progress of rheumatoid arthritis and other types of arthritis, such as arthritis associated with psoriasis. It may reduce the inflammation in your joints and decrease pain, swelling and stiffness. It is generally prescribed as 'Salazopyrin EN'. This is the trade name for sulphasalazine, which is specially coated so that it does not dissolve quickly in the stomach.